Materials and Methods

Factors that may be related to this change were evaluated. There was a significant correlation between age and IIEF-5 score and penile sensorial EMG findings.

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Erection occurs through three different stimuli: Genital stimulation (contact and reflexogenic), central stimulation (non-contact or psychogenic), or stimulation to the central nervous system (night-time) (11). DPN carries sensory innervation from the penile shaft and glans. Therefore, tactile stimulation has an important role in erection (12). Sensory electromyography (EMG) to DPN showed the early occurrence of sensory disturbances in the distal penis (2). Recently, inhibitors of the phosphodiesterase-5 (PDE-5) enzyme have been the most widely used treatment for ED.

Less common

Tadalafil is an effective and well-tolerated treatment for ED (13). Tadalafil at a dose of 5 mg once daily significantly improves ejaculation and orgasm, sexual intercourse and overall satisfaction, and erectile function (14). In this study, we showed the change in penile sensation in men after treatment with ED. Additionally, this topic has not yet been studied in the literature as far as we know. The inclusion of patients using daily therapy for ED regularly was aimed at a clear assessment of outcomes.

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This research has a prospective and controlled study design. A signed consent form was obtained from all patients who volunteered to participate in the study. Ethics Committee approval for this study was obtained from the Ethics Committee of Health Sciences University, Antalya Training and Research Hospital (2020-352), and all steps were planned and conducted following the Declaration of Helsinki and its later amendments. Patients who 10 mg tadalafil started treatment for ED in the andrology outpatient clinic were referred to the study by the secretariat. We included patients with a history of at least 6 months of ED who did not receive any treatment, patients with normal serum levels of testosterone and luteinizing hormones, and patients who were recommended to use tadalafil for 12 weeks. There was a significant correlation between the IIEF-5 score and NCV (r=0.663, p<0.001) and Amplitude (r=0.659, p<0.001). As improvement in IIEF-5 increases, so does improvement in NCV and Amplitude (Table 3). The mean amplitude value in penile sensorial EMG was 4.47±1.32 before treatment, whereas it increased to 5.07±1.60 after treatment (p<0.015).

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Additionally, the mean latency value was 2.14±0.42 before treatment, whereas it increased to 2.32±0.38after treatment (p<0.001).

Parameter	Value	Description
Half-life	17.5 hours	Time for plasma concentration to reduce by half
Time to Peak	2 hours	When maximum plasma concentration occurs
Absorption Rate	Rapid	Absorbed quickly after oral intake
Metabolism	Liver (CYP3A4 enzyme)	Mainly metabolized in the liver

The latency and amplitude parameters in the penile sensorial EMG are used to calculate NCV.

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Patients with a history of hypogonadism, cryptorchidism, varicocele, peripheral neuropathy, uncontrolled diabetes mellitus (hemoglobin a1c >7%), and past and current illicit drug abuse were excluded from the study. The demographic and clinical characteristics of all patients were recorded. All patients participating in the study completed the International Index of Erectile Function (IIEF-5) form and underwent penile EMG examination before and after treatment. Patients were divided into two groups as over 50 years old and under 50 years old. A comparative evaluation was made on the effect of age on the outcomes of treatment and penile sensorial EMG.

Statistical analysis

Electrophysiological studies were planned to be performed between 09:00 and 12:00, at a room temperature of 23 to 25 °C, in a quiet room with dim light, and with the relaxed and awake patient in the supine position. A two-channel electroneuromyography device (Nihon-Kohden-Neuropack, model MEB-2200) was used for recording. Penile sensorial EMG was examined using Clawson’s method. The penis was placed in the concavity of a specially designed Orthoplast penile traction device and stretched to reach its maximum length by pulling from the tip of the glans. A Cunningham incontinence clamp was placed on the glans, and the penis was maintained in tension by holding from the glans.

Use in Specific Populations

An electroencephalography paste was used for the placement of active and reference steel electrodes. The active recording electrode was placed as proximal as possible to the root of the penis. The reference electrode cheap tadalafil was placed 4 cm above the active electrode. The proximal part of the dorsal penile shaft was stimulated orthodromically with an active electrode and the dorsal glans with a reference electrode (15). Categorical data were presented as number and percentages. The increase in these values after treatment was interpreted as an improvement in penile sensation. As a result, it has been shown that the improvement in IIEF-5 provides an improvement in penile sensation (Figure 1).

Area of Investigation	Focus	Potential Impact
Long-term safety studies	Effects of daily use over several years	Increased safety profile data
Combination therapies	Tadalafil with other ED treatments	Enhanced efficacy
New formulations	Extended-release or topical options	Improved user experience
Genetic factors affecting response	Personalized dosing strategies	Tailored medical approaches

Currently, PDE-5 inhibitors are used as first-line therapy in patients presenting with ED.

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Continuous data were evaluated by the Kolmogorov-Smirnov test to verify the normality of the distribution of variables. Normally distributed data were presented as mean + standard deviation, while non-normally distributed data were presented as median and IQR (25-75th). An independent simple t-test was used to compare two independent normally distributed data, while the Mann-Whitney U test was used for the comparison of non-normally distributed data. A paired sample t-test was used to compare two independent normally distributed data, while the Wilcoxon test was used for the comparison of non-normally distributed data. Spearman’s Correlation analysis was used to analyze the parameters related to changes in IIEF scores.

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A p-value of <0.05 was considered statistically significant. Analysis of the dataset was carried out using the IBM Statistical Package for Social Sciences version 23.0 (IBM SPSS Corp.; Armonk, NY, USA). One patient discontinued the treatment with the complaint of myalgia, and the study was continued with 28 patients since another patient did not come to the follow-up visit. The mean age of the patients was 53±9 years. The mean duration of ED was 6.8 months.

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There were 8 (29%) patients with diabetes and 7 (25%) patients with hypertension. The demographic characteristics and comorbidities of the patients are given in Table 1. We showed statistically significant changes in pre-treatment and post-treatment IIEF-5 scores and penile sensorial EMG findings. Pre-treatment IIEF-5 scores of 13±3 were measured as 19±3 after treatment with tadalafil at a daily dose for 12 weeks (p<0.001). This improvement was consistent with the literature. Our literature search did not find any studies reporting normal values of penile sensation during a normal erection.

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In our study, we performed sensorial measurements in patients with ED.

STRONGER ERECTIONS, BETTER SEX

Before treatment, serum levels of testosterone and luteinizing hormone (LH) were measured. Pre- and post-treatment electromyography (EMG) examinations for penile sensation and International Index of Erectile Function (IIEF-5) scoring were performed for each patient. To investigate the effect of tadalafil, used for treating erectile dysfunction (ED) at a daily dose of 5 mg for 12 weeks, on penile sensation. This topic has not yet been studied in the literature yet. Our study demonstrates a quantative increase in penile sensation with the use of tadalafil.

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Erectile dysfunction (ED) is defined as the persistent or recurrent inability to achieve and/or maintain an adequate penile erection for sexual activity (1,2). It significantly affects the quality of life of many male individuals (3). It is also one of the most common sexual health problems, affecting an estimated 18 million men in the ultrasound alone (4). Epidemiological data have shown a high prevalence and incidence of ED worldwide (5). Most men have multiple risk factors for ED, one or more of which may be more predominant, including psychological, neurological, hormonal, arterial, or cavernosal disorders, or a combination thereof (6).

Your questions answered

Traditional electrodiagnostic studies for men with ED include pudendal somatosensory -evoked potentials and delays in bulbocavernosus reflexes. Neither of these two methods alone measures the functions of peripheral sensory nerves. The dorsal nerve of the penis (DPN) is the terminal sensory branch of the pudendal nerve, which carries sensory data from the glans and shaft of the penis (7,8). Sensory and tactile stimulation of the penis play an important role in erectile and sexual function. Interruption of sensory stimulation causes decreased libido, ejaculatory dysfunction, and loss of impotence (9,10). Penile sensorial EMG can provide valuable additional information in the differential diagnosis of ED, particularly allowing the identification of different neurogenic lesion sites (16).

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(17) injected intracavernosal papaverine in 15 patients with ED and compared the results of penile EMG and biopsy examinations.

Parameter	Monitoring Interval	Purpose
Blood Pressure	Baseline, monthly	Cardiovascular safety
Liver Function Tests	Every 3 months	Detect liver impairment
Visual Acuity Tests	Annually	Detect retinal side effects
Erectile Function Assessment	As needed	Evaluate effectiveness

They demonstrated low -amplitude values in 5 patients with diabetes mellitus.

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Penile sensorial EMG is a less-invasive, valuable method for patients with ED, whereas penile biopsy examination did not reveal any specific results. Kayigil and Ergen (18) reported lower amplitude values in the EMG of the corpus cavernosum (CC-EMG) in 45%-65% of patients with ED. (19) included 24 patients, 16 with normal findings on neurological examination, and 8 with diabetic neuropathy. They investigated the sensory conduction velocity in the dorsal penile nerve at rest and after injection of prostaglandin E1.

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The mean nerve conduction velocities (NCV) in EMG was 35.5 m/sec (33.3-41.2) before treatment, and 38.05 m/sec (34.5-43.6) after treatment (p<0.001). The increase in NCV is the most important finding 10mg tadalafil of penile sensorial EMG showing an increase in penile sensation. Thus, the increase in NCV has been interpreted as an improvement in penile sensation. The changes in latency and amplitude values used in the calculation of NCV are given in Table 2. The delta equation (Δ = the amount of change) was created for the IIEF-5 score and penile sensorial EMG findings as post-treatment value minus pre-treatment value. They reported that the mean NCV values increased from 32.3+/-6.7 m/s to 47.4+/− 8.2 m/s after the injection of prostaglandin E1.